T-minus 24 days to DEADLINE.
May. 9th, 2011 11:50 am![[personal profile]](https://www.dreamwidth.org/img/silk/identity/user.png){kind=small}
seanan_mcguire[NOTE: I am a few days behind, due to the convention I attended this past weekend. So I'll be posting several of these today. Sorry about the spam.]
The lower stratosphere. June 12th, 2014.
Freed from its secure lab environment, Alpha-RC007 floated serene and unaware on the air currents of the stratosphere. It did not enjoy freedom; it did not abhor freedom; it did not feel anything, not even the cool breezes holding it aloft. In the absence of a living host, the hybrid virus was inert, waiting for something to come along and shock it into a semblance of life.
On the ground, far away, Dr. Alexander Kellis was weeping without shame over the destruction of his lab, and making dire predictions about what could happen now that his creation was loose in the world. Like Dr. Frankenstein before him, he had created with only the best of intentions, and now found himself facing an uncertain future. His lover tried to soothe him, and was rebuffed by a grief too vast and raw to be put into words.
Alpha-RC007—colloquially known as "the Kellis cure"—did not grieve, or love, or worry about the future. Alpha-RC007 only drifted.
The capsid structure of Alpha-RC007 was superficially identical to the structure of the common rhinovirus, being composed of viral proteins locking together to form an icosahedron. The binding proteins, however, were more closely related to the coronavirus ancestors of the hybrid, creating a series of keys against which no natural immune system could lock itself. The five viral proteins forming the capsid structure were equally mismatched: two from one family, two from the other, and the fifth...
The fifth was purely a credit to the man who constructed it, and had nothing of Nature's handiwork in its construction. It was a tiny protein, smaller even than the diminutive VP4 which made the rhinovirus so infectious, and formed a ring of Velcro-like hooks around the outside of the icosahedron. That little hook was the key to Alpha-RC007's universal infection rate. By latching on and refusing to be dislodged, the virus could take as much time as it needed to find a way to properly colonize its host. Once inside, the other specially tailored traits would have their opportunity to shine. All the man-made protein had to do was buy the time to make it past the walls.
The wind currents eddied around the tiny viral particles, allowing them to drop somewhat lower in the stratosphere. Here, a flock of geese was taking advantage of the air currents at the very edge of the atmospheric layer, their honks sounding through the thin air like car alarms. One, banking to adjust her course, raised a wing just a few inches higher, tilting herself hard to the right and letting her feathers brush through the upper currents.
As her feathers swept through the air, they collected dust and pollen...and a few particles of Alpha-RC007. The hooks on the outside of the virus promptly latched onto the goose's wing, not aware, only reacting to the change in their environment. This was not a suitable host, and so the bulk of the virus remained inert, waiting, letting itself be carried along by its unwitting escort back down to the planet's surface.
Honking loudly, the geese flew on. In the air currents above them, the rest of the viral particles freed from Dr. Alexander Kellis's lab drifted, waiting for their own escorts to come along, scoop them up, and allow them to freely roam the waiting Earth. There is nothing so patient, in this world or any other, as a virus searching for a host.
***
We're looking at clear skies here in the Midwest, with temperatures spiking to a new high for this summer—so grab your sunscreen and plan to spend another lazy weekend staying out of the sun! Pollen counts are projected to be low...
When will you Rise?
The lower stratosphere. June 12th, 2014.
Freed from its secure lab environment, Alpha-RC007 floated serene and unaware on the air currents of the stratosphere. It did not enjoy freedom; it did not abhor freedom; it did not feel anything, not even the cool breezes holding it aloft. In the absence of a living host, the hybrid virus was inert, waiting for something to come along and shock it into a semblance of life.
On the ground, far away, Dr. Alexander Kellis was weeping without shame over the destruction of his lab, and making dire predictions about what could happen now that his creation was loose in the world. Like Dr. Frankenstein before him, he had created with only the best of intentions, and now found himself facing an uncertain future. His lover tried to soothe him, and was rebuffed by a grief too vast and raw to be put into words.
Alpha-RC007—colloquially known as "the Kellis cure"—did not grieve, or love, or worry about the future. Alpha-RC007 only drifted.
The capsid structure of Alpha-RC007 was superficially identical to the structure of the common rhinovirus, being composed of viral proteins locking together to form an icosahedron. The binding proteins, however, were more closely related to the coronavirus ancestors of the hybrid, creating a series of keys against which no natural immune system could lock itself. The five viral proteins forming the capsid structure were equally mismatched: two from one family, two from the other, and the fifth...
The fifth was purely a credit to the man who constructed it, and had nothing of Nature's handiwork in its construction. It was a tiny protein, smaller even than the diminutive VP4 which made the rhinovirus so infectious, and formed a ring of Velcro-like hooks around the outside of the icosahedron. That little hook was the key to Alpha-RC007's universal infection rate. By latching on and refusing to be dislodged, the virus could take as much time as it needed to find a way to properly colonize its host. Once inside, the other specially tailored traits would have their opportunity to shine. All the man-made protein had to do was buy the time to make it past the walls.
The wind currents eddied around the tiny viral particles, allowing them to drop somewhat lower in the stratosphere. Here, a flock of geese was taking advantage of the air currents at the very edge of the atmospheric layer, their honks sounding through the thin air like car alarms. One, banking to adjust her course, raised a wing just a few inches higher, tilting herself hard to the right and letting her feathers brush through the upper currents.
As her feathers swept through the air, they collected dust and pollen...and a few particles of Alpha-RC007. The hooks on the outside of the virus promptly latched onto the goose's wing, not aware, only reacting to the change in their environment. This was not a suitable host, and so the bulk of the virus remained inert, waiting, letting itself be carried along by its unwitting escort back down to the planet's surface.
Honking loudly, the geese flew on. In the air currents above them, the rest of the viral particles freed from Dr. Alexander Kellis's lab drifted, waiting for their own escorts to come along, scoop them up, and allow them to freely roam the waiting Earth. There is nothing so patient, in this world or any other, as a virus searching for a host.
***
We're looking at clear skies here in the Midwest, with temperatures spiking to a new high for this summer—so grab your sunscreen and plan to spend another lazy weekend staying out of the sun! Pollen counts are projected to be low...
When will you Rise?
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no subject
Date: 2011-05-09 06:59 pm (UTC)no subject
Date: 2011-05-09 07:00 pm (UTC)no subject
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Date: 2011-05-09 07:37 pm (UTC)no subject
Date: 2011-05-09 06:59 pm (UTC)I'll just be here in the corner, clicking refresh like a madwoman. ;)
Thank you for writing these--they are keeping me barely contained for Deadline.
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Date: 2011-05-09 07:00 pm (UTC)no subject
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Date: 2011-05-09 07:10 pm (UTC)no subject
Date: 2011-05-09 07:22 pm (UTC)Though now I wonder if the birds can get the original Kellis flu strain, since they can carry influenza. So they get the flu cure, but not the zombie plague (or cancer cure). Stupid waterfowl.
* Does make you wonder if borderline predators/omnivores are getting smaller, since they now have a severe selection pressure against getting bigger than 40 lbs.
** There's a scene at the celebration dinner where Buffy is all like 'I know a guy who ate vat-grown beef and it tasted like teriyaki tofu' and Georgia's parents were all 'yeah, we remember beef, and it really doesn't'.
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Date: 2011-05-09 07:57 pm (UTC)no subject
Date: 2011-05-09 08:17 pm (UTC)* Or Australia, or wherever people decide that ostriches are tasty things to raise.
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Date: 2011-05-10 02:45 am (UTC)no subject
Date: 2011-05-09 11:26 pm (UTC)no subject
Date: 2011-05-10 12:59 am (UTC)no subject
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Date: 2011-05-10 02:46 am (UTC)no subject
Date: 2011-05-10 04:12 am (UTC)no subject
Date: 2011-05-09 10:06 pm (UTC)no subject
Date: 2011-05-09 07:10 pm (UTC)Out of curiosity, can you share a good site about viral hooks? My 30-second Google search was useless, and I'm no longer working with Science Textbooks, or I'd go bug one of my Bio friends for more info.
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Date: 2011-05-09 08:17 pm (UTC)no subject
Date: 2011-05-09 09:02 pm (UTC)no subject
Date: 2011-05-25 01:02 am (UTC)http://www.ncbi.nlm.nih.gov/pmc/articles/PMC523237/
It references something called an AT hook. Perhaps something off of ATP (adenine triphosphate?) Anyway, hope that helps.
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Date: 2011-05-09 07:39 pm (UTC)Oh geez, this line gave me CHILLS. These snippets are delightful and I love them.
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Date: 2011-05-09 07:40 pm (UTC)*refresh refresh refresh*
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Date: 2011-05-09 08:25 pm (UTC)Thank you so very much for posting them!
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Date: 2011-05-09 08:53 pm (UTC)no subject
Date: 2011-05-09 09:53 pm (UTC)no subject
Date: 2011-05-09 10:08 pm (UTC)no subject
Date: 2011-05-09 09:15 pm (UTC)no subject
Date: 2011-05-09 09:54 pm (UTC)(and oooh zombie geese!)
ETA: Well, I guess not zombie geese because of the host business but more like unwitting biological warfare geese.
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Date: 2011-05-09 10:00 pm (UTC)And I (of the "Welcome to the Void" t-shirt) really appreciated the chance to meet you and hear you talk and sing last weekend. Thanks for coming out!
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Date: 2011-05-09 10:31 pm (UTC)Virus floatiness = scaaaawwwy.
Birds are immune to KA. I know I must've seen a discussion on this somewhere -- are reptiles?
Also: Thank you.
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Date: 2011-05-09 10:50 pm (UTC)no subject
Date: 2011-05-10 04:12 am (UTC)I think I'm going to curl up in a corner and make little mewling sounds now...
just finished the reread...
Date: 2011-05-10 04:49 pm (UTC)Re: just finished the reread...
Date: 2011-05-11 02:18 am (UTC)no subject
Date: 2011-06-17 03:01 am (UTC)